Trans-Reactivation: A New Epigenetic Phenomenon Underlying Transcriptional Reactivation of Silenced Genes.

Davide Corona, Vincenzo Cavalieri, Walter Arancio, Maria Cristina Onorati, Antonia M. R. Ingrassia, Walter Arancio, Davide F. V. Corona, Giulio Pavesi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In order to study the role played by cellular RNA pools produced by homologous genomic loci in defining the transcriptional state of a silenced gene, we tested the effect of non-functional alleles of the white gene in the presence of a functional copy of white, silenced by heterochromatin. We found that non-functional alleles of white, unable to produce a coding transcript, could reactivate in trans the expression of a wild type copy of the same gene silenced by heterochromatin. This new epigenetic phenomenon of transcriptional trans-reactivation is heritable, relies on the presence of homologous RNA's and is affected by mutations in genes involved in post-transcriptional gene silencing. Our data suggest a general new unexpected level of gene expression control mediated by homologous RNA molecules in the context of heterochromatic genes.
Original languageEnglish
Pages (from-to)1-21
Number of pages21
JournalPLoS Genetics
Volume11(8):e1005444
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

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