Therapeutic strategies to counteract antibiotic resistance in MRSA biofilm-associated infections

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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) hasemerged as one of the leading cause of persistent human infections.This pathogen is widespread and is able to colonizeasymptomatically about a third of the population causing moderateto severe infections. It is currently considered the most commoncause of nosocomial infections and one of the main cause of deathin hospitalized patients. Due to its high morbidity and mortality rateand its ability to resist to most antibiotics on the market, it wasdefined a “superbug”. Its ability to form biofilm on biotic and abioticsurfaces seems to be the primarily responsible of MRSA antibioticresistance and pervasiveness. Importantly, more than 80% ofbacterial infections are biofilm-mediated. Biofilm formation onindwelling catheters, prosthetic devices and implants is recognizedas cause of serious chronic infections in hospital environment. In thisreview we discussed the most relevant literature of the last five yearsconcerning the development of synthetic small molecules able toinhibit biofilm formation or to eradicate or disperse pre-formedbiofilms in the fight against MRSA diseases. The aim is to provideguidelines for the development of new anti-virulence strategiesbased on the knowledge so far acquired, and, to identify the mainflaws of this research field, which did not allow to obtain new anti-MRSA drugs market-approved able to act against biofilm-associatedinfections
Original languageEnglish
Pages (from-to)65-80
Number of pages16
JournalChemMedChem
Volume16
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • General Pharmacology, Toxicology and Pharmaceutics
  • Organic Chemistry

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