Therapeutic options for homozygous familial hypercholesterolemia: the role of Lomitapide

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Abstract

Lomitapide (Juxtapid® in US and Lojuxta® in Europe) is the first developed inhibitor of the microsomal triglyceride transfer protein (MTP) approved as a novel drug for the management of homozygous familial hypercholesterolemia (HoFH). It acts by binding directly and selectively to MTP thus decreasing the assembly and secretion of the apo-B containing lipoproteins both in the liver and in the intestine.
Original languageEnglish
Pages (from-to)3773-3783
Number of pages11
JournalCurrent Medicinal Chemistry
Volume27
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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