Therapeutic options for homozygous familial hypercholesterolemia: the role of Lomitapide

Research output: Contribution to journalArticle

Abstract

Lomitapide (Juxtapid® in US and Lojuxta® in Europe) is the first developed inhibitor of the microsomal triglyceride transfer protein (MTP) approved as a novel drug for the management of homozygous familial hypercholesterolemia (HoFH). It acts by binding directly and selectively to MTP thus decreasing the assembly and secretion of the apo-B containing lipoproteins both in the liver and in the intestine.
Original languageEnglish
Number of pages9
JournalCurrent Medicinal Chemistry
Publication statusPublished - 2019

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