TY - JOUR
T1 - "..the times they aren't A-Changin'." rTMS does not affect basic mechanisms of temporal discrimination: A pilot study with ERPs
AU - Tarantino, Vincenza
AU - Marzi, null
AU - Avanzini, null
AU - Tarantino, Vincenza
AU - Battista, null
AU - Del Sordo, null
AU - Ragazzoni, null
AU - Viggiano, null
AU - Cincotta, null
AU - Zaccara, null
AU - Giovannelli, null
PY - 2014
Y1 - 2014
N2 - In time processing, the role of different cortical areas is still under investigation. Event-related potentials (ERPs) represent valuable indices of neural timing mechanisms in the millisecond-to-second domain. We used an interference approach by repetitive TMS (rTMS) on ERPs and behavioral performance to investigate the role of different cortical areas in processing basic temporal information. Ten healthy volunteers were requested to decide whether time intervals between two tones (S1-S2, probe interval) were shorter (800 ms), equal to, or longer (1200 ms) than a previously listened 1000-ms interval (target interval) and press different buttons accordingly. This task was performed at the baseline and immediately after a 15-min-long train of 1-Hz rTMS delivered over the supplementary motor area, right posterior parietal cortex, right superior temporal gyrus, or an occipital control area. Task accuracy, reaction time, and ERPs during (contingent negative variation, CNV) and after the presentation of probe intervals were analyzed. At the baseline, CNV amplitude was modulated by the duration of the probe interval. RTMS had no significant effect on behavioral or ERP measures. These preliminary data suggest that stimulated cortical areas are less crucially involved than other brain regions (e.g. subcortical structures) in the explicit discrimination of auditory time intervals in the range of hundreds of milliseconds.
AB - In time processing, the role of different cortical areas is still under investigation. Event-related potentials (ERPs) represent valuable indices of neural timing mechanisms in the millisecond-to-second domain. We used an interference approach by repetitive TMS (rTMS) on ERPs and behavioral performance to investigate the role of different cortical areas in processing basic temporal information. Ten healthy volunteers were requested to decide whether time intervals between two tones (S1-S2, probe interval) were shorter (800 ms), equal to, or longer (1200 ms) than a previously listened 1000-ms interval (target interval) and press different buttons accordingly. This task was performed at the baseline and immediately after a 15-min-long train of 1-Hz rTMS delivered over the supplementary motor area, right posterior parietal cortex, right superior temporal gyrus, or an occipital control area. Task accuracy, reaction time, and ERPs during (contingent negative variation, CNV) and after the presentation of probe intervals were analyzed. At the baseline, CNV amplitude was modulated by the duration of the probe interval. RTMS had no significant effect on behavioral or ERP measures. These preliminary data suggest that stimulated cortical areas are less crucially involved than other brain regions (e.g. subcortical structures) in the explicit discrimination of auditory time intervals in the range of hundreds of milliseconds.
KW - Contingent negative variation
KW - ERP
KW - Timing
KW - Transcranial magnetic stimulation
KW - Contingent negative variation
KW - ERP
KW - Timing
KW - Transcranial magnetic stimulation
UR - http://hdl.handle.net/10447/308085
UR - http://www.elsevier.com/locate/neuroscience
M3 - Article
VL - 278
SP - 302
EP - 312
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
ER -