Ageing is a natural and physiological condition that is the result of compromised stress response,homeostatic imbalance and increased risk of developing diseases. However, if aging with good healthand functions (successful ageing) and aging with disease and disability (unsuccessful ageing) dependson a combination of “positive features”, including genetic, epigenetic and phenotypic characteristicsin combination with favourable environment, economic status and social involvement. In our study,we summarize some key points for the identification of a longevity signature, with a particular focuson long-living Sicilian individuals and centenarians. Analysing three different Sicilian cohorts (young,people with no centenarian parents and long-living individuals (LLI) aged >90) we found APOE e3\e3in our LLIs and no presence of e4. Regarding FOXO rs2802292 G-allele (G>T) we did not observe anassociation with longevity, probably because of the small sample of centenarians studied. Regardinghaematological and anthropometric results, it is still difficult to point specific longevity features and sofar, we cannot specify a single one. On the other hand, we believe that the synergy among genetics andenvironment might create successful interaction to achieve and obtain effective longevity.
- Endocrinology, Diabetes and Metabolism
- Immunology and Allergy
- Physiology (medical)
- Cancer Research