The Role of Nutraceuticals in Statin Intolerant Patients

Angelo Maria Patti, Dragana Nikolic, Manfredi Rizzo, Rosaria Vincenza Giglio, Gani Bajraktari, Maciej Banach, Niki Katsiki, Amirhossein Sahebkar, Giuseppe M.C. Rosano, Christos Pitsavos, Zlatko Fras, Dragan M. Djuric, Dimitri P. Mikhailidis, Bernhard Paulweber, Željko Reiner, Eric Bruckert, Michel Langlois, Maria-Corina Serban, Gyorgy Paragh, Olena MitchenkoDaniel Pella, Marat Ezhov, Olena Mitchenko, Giuseppe M.C. Rosano, Gustavs Latkovskis, Stephan Von Haehling, Dragos Vinereanu, Michal Vrablík, Olivier Descamps, Arrigo F.G. Cicero, Paul Muntner, Jacek Rysz, Demosthenes B. Panagiotakos, Patrick M. Moriarty, Robert S. Rosenson, Giuseppe M.C. Rosano, Atanas G. Atanasov, Gerald F. Watts, Nathan D. Wong, G.B. John Mancini

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)


Statins are the most common drugs administered for patients with cardiovascular disease. However, due to statin-associated muscle symptoms, adherence to statin therapy is challenging in clinical practice. Certain nutraceuticals, such as red yeast rice, bergamot, berberine, artichoke, soluble fiber, and plant sterols and stanols alone or in combination with each other, as well as with ezetimibe, might be considered as an alternative or add-on therapy to statins, although there is still insufficient evidence available with respect to long-term safety and effectiveness on cardiovascular disease prevention and treatment. These nutraceuticals could exert significant lipid-lowering activity and might present multiple non–lipid-lowering actions, including improvement of endothelial dysfunction and arterial stiffness, as well as anti-inflammatory and antioxidative properties. The aim of this expert opinion paper is to provide the first attempt at recommendation on the management of statin intolerance through the use of nutraceuticals with particular attention on those with effective low-density lipoprotein cholesterol reduction.
Original languageEnglish
Pages (from-to)96-118
Number of pages23
JournalJournal of the American College of Cardiology
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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