The role of molecular oxygen in the formation of radiation-engineered multifunctional nanogels

Clelia Dispenza, Maria Antonietta Sabatino, Lorena Anna Ditta, Björn Dahlgren, Clelia Dispenza, Mats Jonsson, Mats Jonsson

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Nanogels are very promising biomedical nanodevices. The classic “radiation chemistry-based” approach to synthetize nanogels consists in the irradiation with pulsed electron beams of dilute, N 2 O-saturated, aqueous solutions of water-soluble polymers of the “crosslinking type”. Nanogels with controlled size and properties are produced in a single irradiation step with no recourse to initiators, organic solvents and surfactants. This paper combines experimental syntheses, performed with two e-beam irradiation setups and dose-ranges, starting from poly(N-vinyl pyrrolidone) solutions of various concentrations, both in N 2 O-saturated and air-saturated initial conditions, with the numerical simulations of the radiation chemistry of aqueous solutions of a radical scavanger exposed to the same irradiation conditions used in the experiments. This approach provides a methodology to predict the impact of system and irradiation conditions on the water radiation chemistry, which in turn affect the nanogel features in terms of molecular and physico-chemical properties. In particular, the crucial role of initial and transient concentration of molecular oxygen is revealed. This work also proposes a very simple and effective methodology to quantitatively measure the double bonds formed in the systems from disporportionation and chain scission reactions, competing with inter-/intra-molecular crosslinking.
Original languageEnglish
Pages (from-to)164-175
Number of pages12
JournalEuropean Polymer Journal
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • General Physics and Astronomy
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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