The relationship between dietary vitamin k and depressive symptoms in late adulthood: A cross-sectional analysis from a large cohort study

Nicola Veronese, Alberto Cester, Francesco Bolzetta, Nicola Veronese, Rosa Reddavide, Lee Smith, Maria Gabriella Caruso, Joseph Firth, Stefano Celotto, Jacopo Demurtas, Ai Koyanagi, Stefania Maggi, Brendon Stubbs, Chiara Cacco, Marianna Noale, Marco Solmi, Maria Notarnicola, Michele Fornaro, Alberto Vaona

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Few studies assessed the associations between dietary vitamin K and depressive symptoms. We aimed to investigate the association between dietary vitamin K and depressive symptoms in a large cohort of North American People. In this cross-sectional analysis, 4,375 participants that were aged 45-79 years from the Osteoarthritis Initiative were included. Dietary vitamin K intake was collected through a semi-quantitative food frequency questionnaire and categorized in quartiles. Depressive symptoms were diagnosed using the 20-item Center for Epidemiologic Studies-Depression (CES-D) ≥ 16. To investigate the associations between vitamin K intake and depressive symptoms, logistic regression analysis were run, which adjusted for potential confounders. Overall, 437 (=10%) subjects had depressive symptoms. After adjusting for 11 confounders, people with the highest dietary vitamin K intake had lower odds of having depressive symptoms (OR = 0.58; 95%CI: 0.43-0.80). This effect was only present in people not taking vitamin D supplementation. In conclusion, higher dietary vitamin K intake was significantly associated with a lower presence of depressive symptoms, also after accounting for potential confounders. Future longitudinal research is required to explore the directionality of the association. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalNutrients
Volume11
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

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