The planimetric Grothoff's criteria by cardiac magnetic resonance can improve the specificity of left ventricular non-compaction diagnosis in thalassemia intermedia

Giuseppina Novo, Salvatore Novo, Daniela Di Lisi, Alessia Pepe, Anna Spasiano, Andrea Barison, Salvatore Novo, Francesca Macaione, Alessandra Spiga, Giuseppina Novo, Antonella Meloni, Daniele Di Lisi, Riccardo Righi, Laura Pistoia, Vincenzo Positano, Saveria Campisi, Alessia Pepe, Francesca Macaione

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Abstract

We differentiated the left ventricle non-compaction (LVNC) from hypertrabeculated myocardium due to a negative remodelingin thalassemia intermedia (TI) patients applying linear and planimetric criteria and comparing the cardiovascular magneticresonance (CMR) findings. CMR images were analyzed in 181 TI patients enrolled in the Myocardial Iron Overloadin Thalassemia Network and 27 patients with proved LVNC diagnosis. The CMR diagnostic criteria applied in TI patientswere: a modified linear CMR Petersen’s criterion based on a more restrictive ratio of diastolic NC/C > 2.5 at segmental leveland the combination of planimetric Grothoff’s criteria (percentage of trabeculated LV myocardial mass LV–MM ≥ 25% ofglobal LV mass and total LV–MMI NC ≥ 15 g/m2). Seventeen TI patients showed at least one positive NC/C segment. Comparedto LVNC patients, these patients showed a lower frequency of segments with non-compaction areas (2.41 ± 1.33 vs5.48 ± 2.26; P < 0.0001), significantly lower LV–MM NC percentage (10.99 ± 4.09 vs 28.20 ± 4.27%; P < 0.0001), LV–MMI(7.58 ± 4.86 vs 19.88 ± 5.02 g/m2; P < 0.0001) and extension of macroscopic fibrosis (0.44 ± 0.18 vs 4.65 ± 2.89; P = 0.004),and significantly higher LV ejection fraction (61.29 ± 5.17 vs 48.50 ± 17.55%; P = 0.016) and cardiac index (4.80 ± 1.49vs 3.46 ± 1.11 l/min/m2; P = 0.002). No TI patient fulfilled the Grothoff’s criteria. All TI patients with an NC/C ratio > 2.5showed morphological and functional CMR parameters significantly different from the patients with a proved diagnosis ofLVNC. Differentiation of LVNC from hypertrabeculated LV in β-TI patients due to a negative heart remodeling depends onthe selected CMR criterion. We suggest using planimetric Grothoff’s criteria to improve the specificity of LVNC diagnosis.
Original languageEnglish
Number of pages8
JournalTHE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Novo, G., Novo, S., Di Lisi, D., Pepe, A., Spasiano, A., Barison, A., Novo, S., Macaione, F., Spiga, A., Novo, G., Meloni, A., Di Lisi, D., Righi, R., Pistoia, L., Positano, V., Campisi, S., Pepe, A., & Macaione, F. (2020). The planimetric Grothoff's criteria by cardiac magnetic resonance can improve the specificity of left ventricular non-compaction diagnosis in thalassemia intermedia. THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING.