The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men

Mario Barbagallo, Ligia Juliana Dominguez Rodriguez, Andrea Ticinesi, Francesca De Vita, Antonio Nouvenne, Fulvio Lauretani, Tiziana Meschi, Elisabetta Dall'Aglio, Gian Paolo Ceda, Marcello Maggio

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The role of nutritional status as determinant of successful aging is very well recognized. There is recent evidence that nutrition may exert its beneficial effects through the modulation of the hormonal anabolic milieu. Under-nutrition and anabolic hormonal deficiency frequently coexist in older individuals determining an increased risk of mobility impairment and adverse outcomes. Mineral dietary assessment has received attention as key component of the nutritional modulation of anabolic status and physical performance. There is evidence that several minerals, including magnesium, exert a positive influence on Insulin-like Growth Factor-1 (IGF-1) secretion in both sexes, and Testosterone (T) in men. In this review we summarize the existing knowledge about the mechanisms by which magnesium can affect T bioactivity in older men. Particular attention will be also devoted to the preliminary observational and intervention studies addressing the relationship between magnesium and T in adult and older individuals. We believe that, if larger studies will confirm these pivotal data, hormonal and mineral strategies might be adopted as synergistic treatment to approach the multifactorial nature of accelerated aging.
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalInternational Journal of Endocrinology
Volume2014
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems

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    Barbagallo, M., Dominguez Rodriguez, L. J., Ticinesi, A., De Vita, F., Nouvenne, A., Lauretani, F., Meschi, T., Dall'Aglio, E., Ceda, G. P., & Maggio, M. (2014). The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men. International Journal of Endocrinology, 2014, 1-9.