The impact of radiotherapy on survival in resectable gastric carcinoma: A meta-analysis of literature data.

Giuseppe Cabibbo, Marco Enea, Anna Licata, Calogero Camma', Barbara Carau, Francesco Fiorica, Stefano Ursino, Francesco Cartei, Calogero Cammà, Alberto Liboni

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

Background: The benefit of external radiotherapy for gastric carcinoma has beenextensively studied, but data on survival are still equivocal.Objective: To assess the effectiveness of surgery combined with preoperative radiotherapy orpostoperative chemoradiotherapy in the reduction of all-cause mortality in patients withresectable gastric carcinoma.Methods: Computerised bibliographic searches of MEDLINE and CANCERLIT (1970–2006) weresupplemented with hand searches of reference lists.Study selection: Studies were included if they were randomised controlled trials (RCTs) comparingmortality of surgery combined with preoperative radiotherapy or postoperative chemoradiotherapyto surgery alone, and if they included patients with histologically-proven gastricadenocarcinoma without metastases. Nine eligible RCTs, 4 of preoperative radiotherapy (832patients) and 5 of postoperative chemoradiotherapy (869 patients), were identified andincluded in the meta-analysis
Original languageEnglish
Pages (from-to)729-740
Number of pages12
JournalCancer Treatment Reviews
Volume33
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Oncology

Fingerprint Dive into the research topics of 'The impact of radiotherapy on survival in resectable gastric carcinoma: A meta-analysis of literature data.'. Together they form a unique fingerprint.

Cite this