The effect of bergamot on dyslipidemia

Angelo Maria Patti, Manfredi Rizzo, Giuseppe Montalto, Dragana Nikolic, Rosaria Vincenza Giglio, Angelo Maria Patti, Niki Katsiki, Dimitri P. Mikhailidis, Khalid Al-Rasadi, Rosaria Vincenza Giglio, Manfredi Rizzo, Ekaterina Ivanova, Giovanni Li Volti, Alexander N. Orekhov, Manfredi Rizzo

Research output: Contribution to journalBook/Film/Article review

14 Citations (Scopus)

Abstract

Background Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evidence This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. Conclusion It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.
Original languageEnglish
Pages (from-to)1175-1181
Number of pages7
JournalPhytomedicine
Volume23
Publication statusPublished - 2016

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Dyslipidemias
Lipids
Citrus
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Dietary Supplements
Flavonoids
Pharmaceutical Preparations
Health
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

The effect of bergamot on dyslipidemia. / Patti, Angelo Maria; Rizzo, Manfredi; Montalto, Giuseppe; Nikolic, Dragana; Giglio, Rosaria Vincenza; Patti, Angelo Maria; Katsiki, Niki; Mikhailidis, Dimitri P.; Al-Rasadi, Khalid; Giglio, Rosaria Vincenza; Rizzo, Manfredi; Ivanova, Ekaterina; Li Volti, Giovanni; Orekhov, Alexander N.; Rizzo, Manfredi.

In: Phytomedicine, Vol. 23, 2016, p. 1175-1181.

Research output: Contribution to journalBook/Film/Article review

Patti, AM, Rizzo, M, Montalto, G, Nikolic, D, Giglio, RV, Patti, AM, Katsiki, N, Mikhailidis, DP, Al-Rasadi, K, Giglio, RV, Rizzo, M, Ivanova, E, Li Volti, G, Orekhov, AN & Rizzo, M 2016, 'The effect of bergamot on dyslipidemia', Phytomedicine, vol. 23, pp. 1175-1181.
Patti, Angelo Maria ; Rizzo, Manfredi ; Montalto, Giuseppe ; Nikolic, Dragana ; Giglio, Rosaria Vincenza ; Patti, Angelo Maria ; Katsiki, Niki ; Mikhailidis, Dimitri P. ; Al-Rasadi, Khalid ; Giglio, Rosaria Vincenza ; Rizzo, Manfredi ; Ivanova, Ekaterina ; Li Volti, Giovanni ; Orekhov, Alexander N. ; Rizzo, Manfredi. / The effect of bergamot on dyslipidemia. In: Phytomedicine. 2016 ; Vol. 23. pp. 1175-1181.
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AB - Background Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evidence This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. Conclusion It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.

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