The cervical fracture as first symptom of multiple myeloma: A case report

Chiara Bellia, Antonino Giulio Giannone, Concetta Scazzone, Daniela Butera, Luisa Agnello, Ada Maria Florena, Giulia Bivona, Marcello Ciaccio, Bruna Lo Sasso, Marcello Ciaccio, Emanuela Pappalardo, Emanuela Pappalardo, Salvatore Milano

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2 Citations (Scopus)


Introduction: Multiple Myeloma (MM) is a clonal disorder characterized by proliferation and accumulation of malignant plasma cells in the bone marrow. Bone disease occurs in approximately 80% of patients with newly diagnosed MM. The cervical spine is the least common site of disease involvement. Case presentation: A 60-year-old female patient was referred to the Department of Neurosurgery for bone pain. A magnetic resonance imaging (MRI) scan showed a pathological fracture of the sixth cervical vertebra (C6). The laboratory tests and the bone marrow examination led to a diagnosis of IgA Ï MM (Durie Salmon stage IIIA). The patient underwent a cervical arthrodesis and started systemic Bortezomib-Thalidomide-Dexamethasone (VTD) combination chemotherapy. During chemiotherapic treatment the patient underwent a vertebroplasty of L4-L5. After 4 VTD cycles, the patient was dismissed showing a very good partial remission (VGPR). Later the patient subjected herself to hematopoietic stem cell transplantation (HSCT) obtaining a complete remission. Discussion: We report a clinical case of MM in which the fracture of cervical spine represents the clinical onset. Indeed this clinical presentation is not common in this type of monoclonal gammopathy. This case underlines the importance of suspecting MM in all cases of compromised bone.
Original languageEnglish
Pages (from-to)535-538
Number of pages4
JournalActa Medica Mediterranea
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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