Synthesis, properties, antitumor and antibacterial activity of new Pt(II) and Pd(II) complexes with 2,2'-dithiobis(benzothiazole) ligand

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28 Citations (Scopus)

Abstract

Mono- and binuclear Pt(II) and Pd(II) complexes with 2,20-dithiobis(benzothiazole) (DTBTA) ligand arereported. [Pt(DTBTA)(DMSO)Cl]Cl∙CHCl3 (1) and [Pd2(m-Cl)2(DTBTA)2]Cl2 (2) have been synthesized andstructurally characterized by elemental analysis, IR, 1H and 13C NMR spectroscopy, MS spectrometryand the content of platinum and palladium was determined using a flame atomic spectrometer. Two differentcoordination modes of 1 and 2 complexes were found; in both complexes, the coordination of Pt(II)and Pd(II) ions involves the N(3) atoms of the ligand but the binuclear complex 2, is a cis-chloro-bridgedpalladium complex. Evaluation of their in vitro antitumor activity against two human tumor cell lineshuman breast cancer (MCF-7) and hepatocellular carcinoma (HepG2); and their antimicrobial activityagainst Escherichia coli and Kokuria rhizophila was performed. Only complex 1 showed a dose- andtime-dependent cytotoxic activity against the two tumor cell lines, associated to apoptosis and accumulationof treated cells in G0/G1 phase of cell cycle, while both 1 and 2 exhibited antimicrobial activitywith complex 1 much more potent. The study on intracellular uptake in both MCF-7 and HepG2 cell linesrevealed that only platinum of complex 1 is present inside the cells, suggesting a different mode of actionof the two compounds. This was also in agreement with the results obtained for the antitumor andantibacterial activity.
Original languageEnglish
Pages (from-to)2378-2386
Number of pages9
JournalBIOORGANIC & MEDICINAL CHEMISTRY
Volume25
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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