A series of substituted 1-(5-bromopyridin-2-yl)-3-[2-(isoindolo[2,1-a]quinoxalin-6-ylamino)ethyl]thiourea and 1-(5-bromopyridin-2-yl)-3-[2-(6-iminoisoindolo[2,1-a]quinoxalin-5(6H)-yl)ethyl]thiourea derivatives were prepared in good yields (63-85%) by reaction betweenthe corresponding amino compounds with 5-bromo-2-isothiocyanatopyridine. All thioureaderivatives, tested for inhibition of HIV-1 RT, showed no significant antiviral activity.
|Number of pages||15|
|Publication status||Published - 2014|
All Science Journal Classification (ASJC) codes
- Organic Chemistry