Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents

Virginia Spano', Anna Carbone, Daniele Giallombardo, Paola Barraja, Barbara Parrino, Girolamo Cirrincione, Patrizia Diana, Alessandra Montalbano, Virginia Spanò, Barbara Parrino, Daniele Giallombardo, Anna Carbone, Alessandra Montalbano, Paola Barraja, Girolamo Cirrincione, Patrizia Diana

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

A series of 40 derivatives of the [1,2]oxazolo[5,4-e]indazoles ring system have been prepared with goodyields using a versatile and convenient route. Annelation of the [1,2]oxazole ring on the indazole-4-onesystem was achieved by reaction of the corresponding enaminoketones with hydroxylamine hydrochloride.Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda andone of them (13t) showed growth-inhibitor activity against all the 54 human tumour cell lines generallyat low micromolar concentrations.
Original languageEnglish
Pages (from-to)6474-6477
Number of pages4
JournalTetrahedron
Volume69
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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