Synthesis, chemical characterization and preliminary in vitro antitumor activityevaluation of new ruthenium(II) complexes with sugar derivatives

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Abstract

Three new complexes of Ru(II), namely [RuCl2(Glun-N,O)2]Na2 (I; Glun = glucosaminate), [RuCl2(1-Tglu)(EtOH)2]Na (II; 1-Tglu = 1-thio-b-D-glucose) and [Ru2(EtOH)6(AL)Cl4] (III; AL=60-aminolactose)were prepared from the same Ru(II) precursor, [RuCl2(DMSO)4] (DMSO = dimethyl sulfoxide). The characterizationof the complexes was carried out by elemental analysis, FT-IR, ES-MS, NMR, EXAFS andDFT calculations. The effectiveness of the complexes on metastatic melanoma A 375 was investigated.The results show that complex II is the most active species.
Original languageEnglish
Pages (from-to)1671-1679
Number of pages9
JournalPolyhedron
Volume30
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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