for their ability to displace specific [3H]flunitrazepam from bovine brain membranes. The substitutionpattern of the above derivatives was shown to influence the receptor affinity. The most active compoundof the series was 7e, showing a 54% inhibition of [3H]flunitrazepam binding. Compounds 7aed,i werecompared with the known isomers chromeno[4,3-c]pyrazole-4(1H)-ones 14aed,i, showing that theisochromene/chromene isomerism influences the activity.
|Number of pages||12|
|Journal||European Journal of Medicinal Chemistry|
|Publication status||Published - 2012|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry