SYNTHESIS AND PHOTOCHEMIOTHERAPEUTIC ACTIVITY OF THIOPYRANO[2,3-E]INDOL-2-ONES

Alessandra Montalbano, Patrizia Diana, Anna Maria Almerico, Girolamo Cirrincione, Antonino Lauria, Paola Barraja, Gaetano Dattolo, Silvia Disarò, Francesco Dall'Acqua, Giampietro Viola, Giuseppe Basso, Laura Sciabica

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Abstract

A series of derivatives of the new ring system thiopyrano[2,3-e]indol-2-one was prepared with the aim of obtaining newphotochemotherapeutic drugs. Biological screenings were performed on this new class of photoactivable drugs and a strong antiproliferativeeffect was observed upon irradiation with UVA light. The compound bearing a methyl substituent at the pyrrole nitrogenresulted as the most interesting showing IC50 in the nanomolar range.
Original languageEnglish
Pages (from-to)2291-2294
Number of pages4
JournalBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume15
Publication statusPublished - 2005

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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