Phenolic compound originated from one of the main class of secondary metabolites, as curcumin and its derivatives have been studied and their biological and pharmacological activities have been evaluated, too [1,2]. Unfortunately, curcumin exhibits poor bioavailability after oral or topic administration .Therefore a carefully designed carrier could significantly facilitate curcumin delivery and broaden the range of its possible pharmaceutical applications. Halloysite was found to be a viable and inexpensive nanoscale container for the encapsulation of biological active molecules .In this communication we report data about a new potential curcumin carrier based on positively charged functionalized halloysite nanotubes with triazolium salts (f-HNT). The interaction between curcumin and f-HNT was investigated by classical techniques as well as the release. Furthermore different cancer cell lines were used to evaluate the potential cytotoxic effect of the drug-carrier system.
|Number of pages||1|
|Publication status||Published - 2014|