Synthesis and biological evaluation of new indazole derivatives

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Abstract

New N-methyl and N-ethyl substitutions in the indazole nucleus are reported by reacting 3-(2-aminobenzamido)indazole and the appropriate trimethyl/triethyl orthobenzoate. Single crystal X-ray analysis confirms the N-ethylation position for the 3-(1-ethyl-1H-indazol-3-yl)-2-phenylquinazolin-4(3H)-one derivative 3f. Compounds 11a-d and 3a-d were tested to evaluate their antimicrobial, their antiproliferative activity and their COX inhibitory activities showing scarce or moderately antiproliferative activity and some inhibitory activity against COX-1 and COX-2.
Original languageEnglish
Pages (from-to)163-177
Number of pages15
JournalArkivoc
Volume2010-07-29
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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