Survival of Patients with Hepatocellular Carcinoma (HCC)Treated by Percutaneous Radio-Frequency Ablation(RFA) Is Affected by Complete Radiological Response

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18 Citations (Scopus)

Abstract

Background: Radio-frequency ablation (RFA) has been employed in the treatment of Barcelona Clinic Liver Cancer (BCLC)early stage hepatocellular carcinoma (HCC) as curative treatments.Aim: To assess the effectiveness and the safety of RFA in patients with early HCC and compensated cirrhosis.Methods: A cohort of 151 consecutive patients with early stage HCC (122 Child-Pugh class A and 29 class B patients) treatedwith RFA were enrolled. Clinical, laboratory and radiological follow-up data were collected from the time of first RFA. Asingle lesion was observed in 113/151 (74.8%), two lesions in 32/151 (21.2%), and three lesions in 6/151 (4%) of patients.Results: The overall survival rates were 94%, 80%, 64%, 49%, and 41% at 12, 24, 36, 48 and 60 months, respectively.Complete response (CR) at 1 month (p,0.0001) and serum albumin levels (p = 0.0004) were the only variablesindipendently linked to survival by multivariate Cox model. By multivariate analysis, tumor size (p = 0.01) is the only variableassociated with an increased likehood of CR. The proportion of major complications after treatment was 4%.Conclusions: RFA is safe and effective for managing HCC with cirrhosis, especially for patients with HCC #3 cm and higherbaseline albumin levels. Complete response after RFA significantly increases survival.
Original languageEnglish
Number of pages7
JournalPLoS One
Volume8
Publication statusPublished - 2013

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hepatoma
Ablation
Radio
radio
Hepatocellular Carcinoma
Survival
Fibrosis
Clinical laboratories
liver neoplasms
serum albumin
Liver Neoplasms
Proportional Hazards Models
Serum Albumin
Liver
multivariate analysis
albumins
Tumors
Albumins
Therapeutics
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

@article{7324bf7b67b44772965ee8d69c46d590,
title = "Survival of Patients with Hepatocellular Carcinoma (HCC)Treated by Percutaneous Radio-Frequency Ablation(RFA) Is Affected by Complete Radiological Response",
abstract = "Background: Radio-frequency ablation (RFA) has been employed in the treatment of Barcelona Clinic Liver Cancer (BCLC)early stage hepatocellular carcinoma (HCC) as curative treatments.Aim: To assess the effectiveness and the safety of RFA in patients with early HCC and compensated cirrhosis.Methods: A cohort of 151 consecutive patients with early stage HCC (122 Child-Pugh class A and 29 class B patients) treatedwith RFA were enrolled. Clinical, laboratory and radiological follow-up data were collected from the time of first RFA. Asingle lesion was observed in 113/151 (74.8{\%}), two lesions in 32/151 (21.2{\%}), and three lesions in 6/151 (4{\%}) of patients.Results: The overall survival rates were 94{\%}, 80{\%}, 64{\%}, 49{\%}, and 41{\%} at 12, 24, 36, 48 and 60 months, respectively.Complete response (CR) at 1 month (p,0.0001) and serum albumin levels (p = 0.0004) were the only variablesindipendently linked to survival by multivariate Cox model. By multivariate analysis, tumor size (p = 0.01) is the only variableassociated with an increased likehood of CR. The proportion of major complications after treatment was 4{\%}.Conclusions: RFA is safe and effective for managing HCC with cirrhosis, especially for patients with HCC #3 cm and higherbaseline albumin levels. Complete response after RFA significantly increases survival.",
author = "Antonio Craxi and Raineri, {Santi Maurizio} and Massimo Midiri and Giuseppe Cabibbo and Antonino Giarratano and {Di Marco}, Vito and Massimo Galia and Calogero Camma' and Giuseppe Butera and Giuseppe Brancatelli and Chiara Genco and Maida, {Marcello Fabio}",
year = "2013",
language = "English",
volume = "8",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",

}

TY - JOUR

T1 - Survival of Patients with Hepatocellular Carcinoma (HCC)Treated by Percutaneous Radio-Frequency Ablation(RFA) Is Affected by Complete Radiological Response

AU - Craxi, Antonio

AU - Raineri, Santi Maurizio

AU - Midiri, Massimo

AU - Cabibbo, Giuseppe

AU - Giarratano, Antonino

AU - Di Marco, Vito

AU - Galia, Massimo

AU - Camma', Calogero

AU - Butera, Giuseppe

AU - Brancatelli, Giuseppe

AU - Genco, Chiara

AU - Maida, Marcello Fabio

PY - 2013

Y1 - 2013

N2 - Background: Radio-frequency ablation (RFA) has been employed in the treatment of Barcelona Clinic Liver Cancer (BCLC)early stage hepatocellular carcinoma (HCC) as curative treatments.Aim: To assess the effectiveness and the safety of RFA in patients with early HCC and compensated cirrhosis.Methods: A cohort of 151 consecutive patients with early stage HCC (122 Child-Pugh class A and 29 class B patients) treatedwith RFA were enrolled. Clinical, laboratory and radiological follow-up data were collected from the time of first RFA. Asingle lesion was observed in 113/151 (74.8%), two lesions in 32/151 (21.2%), and three lesions in 6/151 (4%) of patients.Results: The overall survival rates were 94%, 80%, 64%, 49%, and 41% at 12, 24, 36, 48 and 60 months, respectively.Complete response (CR) at 1 month (p,0.0001) and serum albumin levels (p = 0.0004) were the only variablesindipendently linked to survival by multivariate Cox model. By multivariate analysis, tumor size (p = 0.01) is the only variableassociated with an increased likehood of CR. The proportion of major complications after treatment was 4%.Conclusions: RFA is safe and effective for managing HCC with cirrhosis, especially for patients with HCC #3 cm and higherbaseline albumin levels. Complete response after RFA significantly increases survival.

AB - Background: Radio-frequency ablation (RFA) has been employed in the treatment of Barcelona Clinic Liver Cancer (BCLC)early stage hepatocellular carcinoma (HCC) as curative treatments.Aim: To assess the effectiveness and the safety of RFA in patients with early HCC and compensated cirrhosis.Methods: A cohort of 151 consecutive patients with early stage HCC (122 Child-Pugh class A and 29 class B patients) treatedwith RFA were enrolled. Clinical, laboratory and radiological follow-up data were collected from the time of first RFA. Asingle lesion was observed in 113/151 (74.8%), two lesions in 32/151 (21.2%), and three lesions in 6/151 (4%) of patients.Results: The overall survival rates were 94%, 80%, 64%, 49%, and 41% at 12, 24, 36, 48 and 60 months, respectively.Complete response (CR) at 1 month (p,0.0001) and serum albumin levels (p = 0.0004) were the only variablesindipendently linked to survival by multivariate Cox model. By multivariate analysis, tumor size (p = 0.01) is the only variableassociated with an increased likehood of CR. The proportion of major complications after treatment was 4%.Conclusions: RFA is safe and effective for managing HCC with cirrhosis, especially for patients with HCC #3 cm and higherbaseline albumin levels. Complete response after RFA significantly increases survival.

UR - http://hdl.handle.net/10447/82083

M3 - Book/Film/Article review

VL - 8

JO - PLoS One

JF - PLoS One

SN - 1932-6203

ER -