Abstract

INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE SEQUENCE TYPE 258 PRODUCING K. PNEUMONIAE CARBAPENEMASE 3 (KPC-Kp)HAVE WIDELY EMERGED AND BOTH INDIVIDUAL CASES AND OUTBREAKS OF COLONIZATION OR INFECTION HAVE BEEN REPORTED IN PALERMO, ITALY.OBIETTIVO: THIS IS A RETROSPECTIVE CASE SERIES THAT DESCRIBES THE CLINICAL AND MICROBIOLOGIC OUTCOMES OF 16 PATIENTS WHO RECEIVED A COMBINATION OF HIGH-DOSE TIGECYCLINE AND COLISTIN FOR TREATMENT OF VAP (4 CASES) AND SEVERE BACTERAEMIA (12 CASES) DURING THE YEARS 2009-2011. 11 OUT OF THE 16 CASES WERE POST SURGICAL PATIENTS WITH INTRABDOMINAL ABSCESSES DUE TO KPC-Kp. IN 5 CASES COMBINED KPC-Kp AND CARBAPENEM-RESISTANT ACINETOBACTER BAUMANNII INFECTION WAS ALSO OBSERVED.RISULTATI: CLINICAL EFFICACY WAS ASSESSED IN ALL 16 PATIENTS, WITH 14 OF THEM HAVING A POSITIVE OUTCOME, DEFINED AS EITHER CLINICAL IMPROVEMENT OR CLINICAL CURE. a CLINICAL SUCCESS APPEARED TO BE MUCH MORE FREQUENT THA THAT PREVIOUSLY REPORTED WITH COLISTIN MONOTHERAPY.CONCLUSIONE: STUDIES EVALUATING COMBINATION THERAPY AND WELL-CONTROLLED CLINICAL TRIALS ARE NEEDED TO DEFINED THE OPTIMAL TREATMENT OF INFECTIOUS CAUSED BY KPC-KpAND, MORE GENERALLLY, CARBAPENEM-RESISTANT BACTERIA.
Original languageEnglish
Number of pages0
Publication statusPublished - 2011

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Colistin
Klebsiella pneumoniae
Carbapenems
Clone Cells
Acinetobacter Infections
Tacrine
Acinetobacter baumannii
Controlled Clinical Trials
Bacteremia
Infection
Abscess
Italy
Disease Outbreaks
Therapeutics
Bacteria
tigecycline

Cite this

@conference{0253068da09d4c0bb39e47709506ba03,
title = "Successful treatment of KPC-3 Klebsiella Pneumoniae ST258 clone with a combination of high-dose tigecycline and colistin in ICU: a case series report.",
abstract = "INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE SEQUENCE TYPE 258 PRODUCING K. PNEUMONIAE CARBAPENEMASE 3 (KPC-Kp)HAVE WIDELY EMERGED AND BOTH INDIVIDUAL CASES AND OUTBREAKS OF COLONIZATION OR INFECTION HAVE BEEN REPORTED IN PALERMO, ITALY.OBIETTIVO: THIS IS A RETROSPECTIVE CASE SERIES THAT DESCRIBES THE CLINICAL AND MICROBIOLOGIC OUTCOMES OF 16 PATIENTS WHO RECEIVED A COMBINATION OF HIGH-DOSE TIGECYCLINE AND COLISTIN FOR TREATMENT OF VAP (4 CASES) AND SEVERE BACTERAEMIA (12 CASES) DURING THE YEARS 2009-2011. 11 OUT OF THE 16 CASES WERE POST SURGICAL PATIENTS WITH INTRABDOMINAL ABSCESSES DUE TO KPC-Kp. IN 5 CASES COMBINED KPC-Kp AND CARBAPENEM-RESISTANT ACINETOBACTER BAUMANNII INFECTION WAS ALSO OBSERVED.RISULTATI: CLINICAL EFFICACY WAS ASSESSED IN ALL 16 PATIENTS, WITH 14 OF THEM HAVING A POSITIVE OUTCOME, DEFINED AS EITHER CLINICAL IMPROVEMENT OR CLINICAL CURE. a CLINICAL SUCCESS APPEARED TO BE MUCH MORE FREQUENT THA THAT PREVIOUSLY REPORTED WITH COLISTIN MONOTHERAPY.CONCLUSIONE: STUDIES EVALUATING COMBINATION THERAPY AND WELL-CONTROLLED CLINICAL TRIALS ARE NEEDED TO DEFINED THE OPTIMAL TREATMENT OF INFECTIOUS CAUSED BY KPC-KpAND, MORE GENERALLLY, CARBAPENEM-RESISTANT BACTERIA.",
keywords = "ABSCESS, ICU, KPC-Kp, VAP",
author = "Gaspare Gulotta and Raineri, {Santi Maurizio} and Celestino Bonura and Gianni Pantuso and Andrea Cortegiani and Antonino Giarratano and Antonino Agrusa and {Di Carlo}, Paola and Gianfranco Cocorullo and Anna Giammanco and Caterina Mammina",
year = "2011",
language = "English",

}

TY - CONF

T1 - Successful treatment of KPC-3 Klebsiella Pneumoniae ST258 clone with a combination of high-dose tigecycline and colistin in ICU: a case series report.

AU - Gulotta, Gaspare

AU - Raineri, Santi Maurizio

AU - Bonura, Celestino

AU - Pantuso, Gianni

AU - Cortegiani, Andrea

AU - Giarratano, Antonino

AU - Agrusa, Antonino

AU - Di Carlo, Paola

AU - Cocorullo, Gianfranco

AU - Giammanco, Anna

AU - Mammina, Caterina

PY - 2011

Y1 - 2011

N2 - INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE SEQUENCE TYPE 258 PRODUCING K. PNEUMONIAE CARBAPENEMASE 3 (KPC-Kp)HAVE WIDELY EMERGED AND BOTH INDIVIDUAL CASES AND OUTBREAKS OF COLONIZATION OR INFECTION HAVE BEEN REPORTED IN PALERMO, ITALY.OBIETTIVO: THIS IS A RETROSPECTIVE CASE SERIES THAT DESCRIBES THE CLINICAL AND MICROBIOLOGIC OUTCOMES OF 16 PATIENTS WHO RECEIVED A COMBINATION OF HIGH-DOSE TIGECYCLINE AND COLISTIN FOR TREATMENT OF VAP (4 CASES) AND SEVERE BACTERAEMIA (12 CASES) DURING THE YEARS 2009-2011. 11 OUT OF THE 16 CASES WERE POST SURGICAL PATIENTS WITH INTRABDOMINAL ABSCESSES DUE TO KPC-Kp. IN 5 CASES COMBINED KPC-Kp AND CARBAPENEM-RESISTANT ACINETOBACTER BAUMANNII INFECTION WAS ALSO OBSERVED.RISULTATI: CLINICAL EFFICACY WAS ASSESSED IN ALL 16 PATIENTS, WITH 14 OF THEM HAVING A POSITIVE OUTCOME, DEFINED AS EITHER CLINICAL IMPROVEMENT OR CLINICAL CURE. a CLINICAL SUCCESS APPEARED TO BE MUCH MORE FREQUENT THA THAT PREVIOUSLY REPORTED WITH COLISTIN MONOTHERAPY.CONCLUSIONE: STUDIES EVALUATING COMBINATION THERAPY AND WELL-CONTROLLED CLINICAL TRIALS ARE NEEDED TO DEFINED THE OPTIMAL TREATMENT OF INFECTIOUS CAUSED BY KPC-KpAND, MORE GENERALLLY, CARBAPENEM-RESISTANT BACTERIA.

AB - INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE SEQUENCE TYPE 258 PRODUCING K. PNEUMONIAE CARBAPENEMASE 3 (KPC-Kp)HAVE WIDELY EMERGED AND BOTH INDIVIDUAL CASES AND OUTBREAKS OF COLONIZATION OR INFECTION HAVE BEEN REPORTED IN PALERMO, ITALY.OBIETTIVO: THIS IS A RETROSPECTIVE CASE SERIES THAT DESCRIBES THE CLINICAL AND MICROBIOLOGIC OUTCOMES OF 16 PATIENTS WHO RECEIVED A COMBINATION OF HIGH-DOSE TIGECYCLINE AND COLISTIN FOR TREATMENT OF VAP (4 CASES) AND SEVERE BACTERAEMIA (12 CASES) DURING THE YEARS 2009-2011. 11 OUT OF THE 16 CASES WERE POST SURGICAL PATIENTS WITH INTRABDOMINAL ABSCESSES DUE TO KPC-Kp. IN 5 CASES COMBINED KPC-Kp AND CARBAPENEM-RESISTANT ACINETOBACTER BAUMANNII INFECTION WAS ALSO OBSERVED.RISULTATI: CLINICAL EFFICACY WAS ASSESSED IN ALL 16 PATIENTS, WITH 14 OF THEM HAVING A POSITIVE OUTCOME, DEFINED AS EITHER CLINICAL IMPROVEMENT OR CLINICAL CURE. a CLINICAL SUCCESS APPEARED TO BE MUCH MORE FREQUENT THA THAT PREVIOUSLY REPORTED WITH COLISTIN MONOTHERAPY.CONCLUSIONE: STUDIES EVALUATING COMBINATION THERAPY AND WELL-CONTROLLED CLINICAL TRIALS ARE NEEDED TO DEFINED THE OPTIMAL TREATMENT OF INFECTIOUS CAUSED BY KPC-KpAND, MORE GENERALLLY, CARBAPENEM-RESISTANT BACTERIA.

KW - ABSCESS

KW - ICU

KW - KPC-Kp

KW - VAP

UR - http://hdl.handle.net/10447/63816

M3 - Other

ER -