Study of molecular mechanism involved in neuronal plasticity induced by magnetic stimulation in cultured hippocampal neurons

Frinchi, M.; Woods, K.

Research output: Contribution to conferencePaper

Abstract

Although a large number of investigations have shown that transcranial magnetic stimulation, a non-invasive method of brain stimulation with minimal side effects, is able to induce neuronal synaptic plastic change, very few studies have examined the molecular mechanisms of magnetic stimulation involved in synaptic plasticity. Since it is well known that neurotrophins and their receptors regulate synaptic strength and thereby mediate plasticity, in this study we have investigated the effects of low-frequency (1 Hz) magnetic stimulation, at different intensities, on the activation of neurotrophic factors receptors and relative intracellular pathways in primary cultures of hippocampal neurons. The results showed that one single exposure to magnetic stimulation, low-frequency and 1.55 tesla intensity, activates Glial cell-derived neurotrophic factor receptor (RET), Brain-derived neurotrophic factor receptor (TrkB), Fibroblasts growth factor 2 receptor 1 (FGFR1) and PI3K/Akt pathway in primary cultures of hippocampal neurons after only a short time (5 minutes). These data may explain, at least in part, the mechanism through which magnetic stimulation enhances synaptic plasticity. Our current studies are characterizing the mechanism of neurotrophic factor receptor activation following magnetic stimulation, including the role of neurotransmitters release.
Original languageEnglish
Publication statusPublished - 2014

Cite this

Study of molecular mechanism involved in neuronal plasticity induced by magnetic stimulation in cultured hippocampal neurons. / Frinchi, M.; Woods, K.

2014.

Research output: Contribution to conferencePaper

@conference{069c142b9e3d489cbf76c963ffed0b27,
title = "Study of molecular mechanism involved in neuronal plasticity induced by magnetic stimulation in cultured hippocampal neurons",
abstract = "Although a large number of investigations have shown that transcranial magnetic stimulation, a non-invasive method of brain stimulation with minimal side effects, is able to induce neuronal synaptic plastic change, very few studies have examined the molecular mechanisms of magnetic stimulation involved in synaptic plasticity. Since it is well known that neurotrophins and their receptors regulate synaptic strength and thereby mediate plasticity, in this study we have investigated the effects of low-frequency (1 Hz) magnetic stimulation, at different intensities, on the activation of neurotrophic factors receptors and relative intracellular pathways in primary cultures of hippocampal neurons. The results showed that one single exposure to magnetic stimulation, low-frequency and 1.55 tesla intensity, activates Glial cell-derived neurotrophic factor receptor (RET), Brain-derived neurotrophic factor receptor (TrkB), Fibroblasts growth factor 2 receptor 1 (FGFR1) and PI3K/Akt pathway in primary cultures of hippocampal neurons after only a short time (5 minutes). These data may explain, at least in part, the mechanism through which magnetic stimulation enhances synaptic plasticity. Our current studies are characterizing the mechanism of neurotrophic factor receptor activation following magnetic stimulation, including the role of neurotransmitters release.",
author = "{Frinchi, M.; Woods, K.} and Filippo Brighina and Brigida Fierro and Natale Belluardo and Giuseppa Mudo' and Giuseppe Cosentino and {Di Liberto}, Valentina",
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TY - CONF

T1 - Study of molecular mechanism involved in neuronal plasticity induced by magnetic stimulation in cultured hippocampal neurons

AU - Frinchi, M.; Woods, K.

AU - Brighina, Filippo

AU - Fierro, Brigida

AU - Belluardo, Natale

AU - Mudo', Giuseppa

AU - Cosentino, Giuseppe

AU - Di Liberto, Valentina

PY - 2014

Y1 - 2014

N2 - Although a large number of investigations have shown that transcranial magnetic stimulation, a non-invasive method of brain stimulation with minimal side effects, is able to induce neuronal synaptic plastic change, very few studies have examined the molecular mechanisms of magnetic stimulation involved in synaptic plasticity. Since it is well known that neurotrophins and their receptors regulate synaptic strength and thereby mediate plasticity, in this study we have investigated the effects of low-frequency (1 Hz) magnetic stimulation, at different intensities, on the activation of neurotrophic factors receptors and relative intracellular pathways in primary cultures of hippocampal neurons. The results showed that one single exposure to magnetic stimulation, low-frequency and 1.55 tesla intensity, activates Glial cell-derived neurotrophic factor receptor (RET), Brain-derived neurotrophic factor receptor (TrkB), Fibroblasts growth factor 2 receptor 1 (FGFR1) and PI3K/Akt pathway in primary cultures of hippocampal neurons after only a short time (5 minutes). These data may explain, at least in part, the mechanism through which magnetic stimulation enhances synaptic plasticity. Our current studies are characterizing the mechanism of neurotrophic factor receptor activation following magnetic stimulation, including the role of neurotransmitters release.

AB - Although a large number of investigations have shown that transcranial magnetic stimulation, a non-invasive method of brain stimulation with minimal side effects, is able to induce neuronal synaptic plastic change, very few studies have examined the molecular mechanisms of magnetic stimulation involved in synaptic plasticity. Since it is well known that neurotrophins and their receptors regulate synaptic strength and thereby mediate plasticity, in this study we have investigated the effects of low-frequency (1 Hz) magnetic stimulation, at different intensities, on the activation of neurotrophic factors receptors and relative intracellular pathways in primary cultures of hippocampal neurons. The results showed that one single exposure to magnetic stimulation, low-frequency and 1.55 tesla intensity, activates Glial cell-derived neurotrophic factor receptor (RET), Brain-derived neurotrophic factor receptor (TrkB), Fibroblasts growth factor 2 receptor 1 (FGFR1) and PI3K/Akt pathway in primary cultures of hippocampal neurons after only a short time (5 minutes). These data may explain, at least in part, the mechanism through which magnetic stimulation enhances synaptic plasticity. Our current studies are characterizing the mechanism of neurotrophic factor receptor activation following magnetic stimulation, including the role of neurotransmitters release.

UR - http://hdl.handle.net/10447/98820

M3 - Paper

ER -