Spontaneous chronic subdural hematomas in young adults with a deficiency in coagulation factor XIII. Report of three cases

Antonio Pinto, Antonino Tuttolomondo, Giuseppe Licata, Giuseppe Licata, Giovanni Sabatino, Annunziato Mangiola, Alessio Albanese, Antonino Pinto, Antonio Tuttolomondo, Angelo Pompucci, Carmelo Anile

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Abstract

Chronic subdural hematomas (SDHs) generally occur in elderly patients. Its pathogenesis is usually related to head trauma with tearing and rupture of the bridging veins, although in some cases a history of trauma is not recognizable. There are many reports regarding the association between spontaneous chronic SDHs and an alteration in coagulative parameters. A coagulative disorder should be suspected when an unexplained hemorrhage occurs, especially in a young patient. The authors report on three young men with a deficiency in coagulation factor XIII (FXIII) who underwent surgery for chronic SDHs. The role of FXIII in the pathogenesis of chronic SDH is emphasized. In patients with unexplained chronic SDH all coagulation parameters and factors should be screened to identify an eventual coagulative disorder.
Original languageEnglish
Pages (from-to)1130-1132
Number of pages3
JournalJOURNAL OF NEUROSURGERY
Volume102
Publication statusPublished - 2005

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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    Pinto, A., Tuttolomondo, A., Licata, G., Licata, G., Sabatino, G., Mangiola, A., Albanese, A., Pinto, A., Tuttolomondo, A., Pompucci, A., & Anile, C. (2005). Spontaneous chronic subdural hematomas in young adults with a deficiency in coagulation factor XIII. Report of three cases. JOURNAL OF NEUROSURGERY, 102, 1130-1132.