Sorafenib in Mice – A Pharmacokinetic Study.

Gennara Cavallaro, Emanuela Fabiola Craparo, Roberto A. Abbiati, Davide Manca

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Pharmacokinetic models are applied to determine the drug distribution in the organism with respect to a givenadministration. Models based on body anatomy and physiology can provide an accurate description of drugconcentrations reached in specific organs and tissues of mammals. This article proposes a model based onmammalian anatomy and physiology to predict the biodistribution in mice of sorafenib, an anti-cancer drug,with specific attention to the concentration reached in the liver, as that is the action site in case ofhepatocellular carcinoma treatment. The model reveals a close correspondence respect to experimentalconcentration data in the organism and also assesses with good fidelity the enterohepatic circulation, aphenomenon occurring at the liver-intestine level and that strongly characterizes sorafenib distribution.
Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalCHEMICAL ENGINEERING TRANSACTIONS
Volume43
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • General Chemical Engineering

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