Some genotypic and environmental conditions of the host in cutaneous malignant melanoma.

Research output: Contribution to journalArticle

Abstract

The factors involving the development of melanoma vary according to the phenotype and environment conditions experienced by the host MC1R variant alleles that are associated with increased melanoma risk are likely to sensitize melanocytes to DNA damage by ultraviolet (UV) exposure, and the interactions between UV radiation and the genome induce melanoma. In fact, the non-functional MC1R cells have a very slow rate of cyclobutane pyrimidine dimers removal. The most significant mutations induced by UV in the skin occur in the CDKN2A gene being the major target of UV, that encodes 2 distinct proteins cell cycle regulators: p16INK4A and p14ARF. Inactivation of both tumor suppressors results in escape from cell cycle arrest because of disruption of the G1/S restriction point The outcome is premature cell cycle progression and incomplete repair of DNA damage that leads to genomic instability and mutations. In fact, the signaling pathways of UV in melanocytes reveal the complex interrelationship between the pathways that regulate survival, proliferation and melanogenesis
Original languageEnglish
Pages (from-to)465-469
Number of pages5
JournalGiornale Italiano di Dermatologia e Venereologia
Volume141
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

@article{c288a56ebd5a48ee991180926d2223a1,
title = "Some genotypic and environmental conditions of the host in cutaneous malignant melanoma.",
abstract = "The factors involving the development of melanoma vary according to the phenotype and environment conditions experienced by the host MC1R variant alleles that are associated with increased melanoma risk are likely to sensitize melanocytes to DNA damage by ultraviolet (UV) exposure, and the interactions between UV radiation and the genome induce melanoma. In fact, the non-functional MC1R cells have a very slow rate of cyclobutane pyrimidine dimers removal. The most significant mutations induced by UV in the skin occur in the CDKN2A gene being the major target of UV, that encodes 2 distinct proteins cell cycle regulators: p16INK4A and p14ARF. Inactivation of both tumor suppressors results in escape from cell cycle arrest because of disruption of the G1/S restriction point The outcome is premature cell cycle progression and incomplete repair of DNA damage that leads to genomic instability and mutations. In fact, the signaling pathways of UV in melanocytes reveal the complex interrelationship between the pathways that regulate survival, proliferation and melanogenesis",
author = "Mario Arico' and Giuseppe Pistone and Bongiorno, {Maria Rita}",
year = "2006",
language = "English",
volume = "141",
pages = "465--469",
journal = "Giornale Italiano di Dermatologia e Venereologia",
issn = "0392-0488",
publisher = "Edizioni Minerva Medica S.p.A.",

}

TY - JOUR

T1 - Some genotypic and environmental conditions of the host in cutaneous malignant melanoma.

AU - Arico', Mario

AU - Pistone, Giuseppe

AU - Bongiorno, Maria Rita

PY - 2006

Y1 - 2006

N2 - The factors involving the development of melanoma vary according to the phenotype and environment conditions experienced by the host MC1R variant alleles that are associated with increased melanoma risk are likely to sensitize melanocytes to DNA damage by ultraviolet (UV) exposure, and the interactions between UV radiation and the genome induce melanoma. In fact, the non-functional MC1R cells have a very slow rate of cyclobutane pyrimidine dimers removal. The most significant mutations induced by UV in the skin occur in the CDKN2A gene being the major target of UV, that encodes 2 distinct proteins cell cycle regulators: p16INK4A and p14ARF. Inactivation of both tumor suppressors results in escape from cell cycle arrest because of disruption of the G1/S restriction point The outcome is premature cell cycle progression and incomplete repair of DNA damage that leads to genomic instability and mutations. In fact, the signaling pathways of UV in melanocytes reveal the complex interrelationship between the pathways that regulate survival, proliferation and melanogenesis

AB - The factors involving the development of melanoma vary according to the phenotype and environment conditions experienced by the host MC1R variant alleles that are associated with increased melanoma risk are likely to sensitize melanocytes to DNA damage by ultraviolet (UV) exposure, and the interactions between UV radiation and the genome induce melanoma. In fact, the non-functional MC1R cells have a very slow rate of cyclobutane pyrimidine dimers removal. The most significant mutations induced by UV in the skin occur in the CDKN2A gene being the major target of UV, that encodes 2 distinct proteins cell cycle regulators: p16INK4A and p14ARF. Inactivation of both tumor suppressors results in escape from cell cycle arrest because of disruption of the G1/S restriction point The outcome is premature cell cycle progression and incomplete repair of DNA damage that leads to genomic instability and mutations. In fact, the signaling pathways of UV in melanocytes reveal the complex interrelationship between the pathways that regulate survival, proliferation and melanogenesis

UR - http://hdl.handle.net/10447/28635

UR - https://www.minervamedica.it/en/journals/dermatologia-venereologia/issue.php?cod=R23Y2006N05

M3 - Article

VL - 141

SP - 465

EP - 469

JO - Giornale Italiano di Dermatologia e Venereologia

JF - Giornale Italiano di Dermatologia e Venereologia

SN - 0392-0488

ER -