Solution structure of R2Sn(IV)-β-N-Acetyl-Neuraminate (R=Me, Bu) complexes in D2O and DMSO-d6: experimental NMR and DFT computational study.

Francesco Ferrante, Lorenzo Pellerito, Girolamo Casella, Enrico Rotondo, Archimede Rotondo, Nuccio Bertazzi

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Abstract

Two diorganotin(IV)–NANA complexes (NANA (1) = b-N-acetyl-Neuraminic Acid =5-amino-3,5-dideoxy-D-glycero-b-D-galactononulosic acid) with formula Me2Sn(IV)NANA (2) andBu2Sn(IV)NANA (3) were synthesized and characterized by 1H, 13C and 119Sn NMR spectroscopy, bothin D2O and DMSO-d6 solutions. The experimental data in DMSO suggested the monosaccharidebidentate chelation via O1 carboxylate and vicinal O2 alkoxide atoms, which, in D2O, can bedynamically extended to a third binding site (O8 atom) of the pendant chain. Coordination at the tinatom is discussed on the basis of experimental NMR data and DFT calculation.
Original languageEnglish
Pages (from-to)1440-1446
Number of pages7
JournalDalton Transactions
Volume14
Publication statusPublished - 2007

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All Science Journal Classification (ASJC) codes

  • Inorganic Chemistry

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