Soluble CD40L and cardiovascular risk in asymptomatic low-grade carotid stenosis

Giuseppina Novo, Carlo Maria Barbagallo, Salvatore Novo, Egle Corrado, Angela Falco, Stefania Basili, Giovanni Davì, Rosalba Tantillo, Valentina Davi'

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50 Citations (Scopus)


BACKGROUND AND PURPOSE:We investigated whether soluble CD40L (sCD40L) may predict the risk of cardiovascular (CV) events in patients with asymptomatic carotid plaques.METHODS:Forty-two patients with asymptomatic low-grade carotid stenosis (ALCS) and 21 controls without any carotid stenosis were enrolled. All subjects had at least a major cardiovascular risk factor (CRF). Plasma levels of C-reactive protein (CRP), IL-6, and sCD40L were measured. Subjects were reviewed every 12 months (median follow-up, 8 years).RESULTS:ALCS patients had higher (P<0.0001) CRP, IL-6, and sCD40L than controls. Fourteen patients experienced a CV event. Cox regression analysis showed that only high sCD40L levels (P=0.003) independently predicted cardiovascular risk.CONCLUSIONS:High levels of sCD40L may predict the risk of CV events in ALCS.
Original languageEnglish
Pages (from-to)673-675
Number of pages3
Publication statusPublished - 2005

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

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