“SINDROME DI BECHET, CELIACHIA E DIABETE MELLITO DI I TIPO”: ....RARO CASO A TIPIZZAZIONE ANOMALA

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Abstract

[automatically translated] Behcet's disease is a rare disease, Autoimmune, multifactorial onset between the second and third decades of life, with the highest incidence in the so-called territories of the Silk Road (Middle East) as well as, in the Mediterranean Basin. In Europe the prevalence is 1: 500,000 with a higher incidence in females. It is clinically characterized by recurrent ulcerative lesions of the oral cavity that are accompanied by skin lesions or genital ulcers, eye or pathergy Positive. The "Behcet's Disease International Study Group" identified in the presence of oral ulcers associated with two of the lesions sovracitate the clinical diagnosis of Behcet's disease. In 60-70% of cases it is described an association with HLA-B51 phenotype. Despite being based autoimmune disease, hardly associated with other clinical manifestations such as Celiac disease, diabetes, Crohn et al. The authors describe a case report of a 24 year old girl already suffering from diabetes mellitus and celiac disease, came to our attention for ulcerative necrotic lesions of the palatine tonsil to left, from about 20 days. The initial tentative diagnosis of Behcet's disease had been discarded by the absence of symptoms or signs associated, as well as for typing of the HLA system tested positive for MHC-II B-63. Counseling rheumatology confirmed a diagnosis of celiac disease because the oral manifestations were compatible with an evolutionary phase of the same (positive in 25% of patients with celiac disease). The progression of dependent ulcerotici phenomena ipsilateral tonsil and the occurrence of similar events in charge of contralateral tonsil, in a phase of apparent quiescence of celiac disease, prompted the authors to hypothesize the presence of Behcet's disease, although this is associated to other autoimmune diseases only in 2-4% of cases. Only excisional biopsy and the appearance after months of genital lesions, allowed a diagnosis of certainty of a rare association, the fourth to date described in the literature, of Diabetes Mellitus Type I, celiac disease, and Behcet's disease in atypical typing. although this is associated with other autoimmune diseases only in 2-4% of cases. Only excisional biopsy and the appearance after months of genital lesions, allowed a diagnosis of certainty of a rare association, the fourth to date described in the literature, of Diabetes Mellitus Type I, celiac disease, and Behcet's disease in atypical typing. although this is associated with other autoimmune diseases only in 2-4% of cases. Only excisional biopsy and the appearance after months of genital lesions, allowed a diagnosis of certainty of a rare association, the fourth to date described in the literature, of Diabetes Mellitus Type I, celiac disease, and Behcet's disease in atypical typing.
Original languageItalian
Number of pages0
Publication statusPublished - 2011

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