Sicilian centenarian offspring are more resistant to immune ageing

Matteo Bulati, Anna Aiello, Caterina Maria Gambino, Giulia Accardi, Calogero Caruso, Graziella Rubino, Francesco Gervasi, Stefano Aprile

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Immunosenescence constitutes a major indirect cause of morbidity and mortality in the elderly. Previous analysis of immune signatures in a cohort of centenarian offspring showed an intermediate immunophenotype between age-matched and younger controls. Aims: To confirm and extend the previous studies performing further phenotypical analysis in centenarian offspring and controls. Methods: Analysis of Treg cells, γδ T cells, mucosal-associated invariant T cells, and senescent immune T cells was performed in centenarian offspring and controls. Results: We report significant differences between elderly and centenarian offspring in most of the studied subsets, showing that centenarian offspring subsets present an intermediate phenotyping between elderly and younger people. Conclusion: The whole present data confirm and extend the previous results showing that centenarian offspring retain more youthful immunological parameters and that the exhaustion of the immune system is less evident than in elderly without centenarian parents, though further investigations are warranted.
Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalAging clinical and experimental research
Volume31
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

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