SHORT-TERM VARIABILITY OF 24-H SYSTOLIC BLOOD PRESSURE IS ASSOCIATED WITH MICROALBUMINURIA IN PATIENTS WITH PRIMARY HYPERTENSION

Giulio Geraci, Giuseppe Mule', Laura Guarino, Santina Cottone, Anna Carola Foraci, Antonella Castiglia, Francesco D'Ignoto

Research output: Contribution to journalMeeting Abstract

Abstract

Introduction: Limited and conflicting data are availableabout the association between short-term blood pressure(BP) variability and urinary albumin excretion rate(uAER).Aim: To analyse the relationships between microalbuminuria,defined as an uAER between 20 and200 lg/min, and short-term BP variability, assessed asaverage real variability (ARV), weighted standard deviation(SD) of 24-h BP, and as SD of daytime and nighttimeBP.Methods: The study population consisted of 316 untreatedessential hypertensive patients with normal estimatedglomerular filtration rate ([60 ml/min/1.73m2), whichunderwent 24-h ambulatory BP monitoring and 24-h uAERdetermination.Results: Microalbuminuria was detected in 83 (26 %)patients. ARV of 24-h systolic BP (SBP) was significantlyhigher in patients with microalbuminuria [9.9 (8.6–11.1)mmHg] when compared to those without it [9.1 (8–10.2)mmHg; p = 0.007]. This difference held (p = 0.026) afteradjustment for age, mean levels of BP and other potentialconfounders by ANCOVA. The correlation analysis disclosedthat, among the indices of short-term BPV, onlyARV of 24-h SBP (r = 0.17; p = 0.003) and ARV of 24-hDBP (r = 0.13; p = 0.03) were significantly related to(Log) uAER, whereas the relationships of uAER with SDof daytime SBP and with weighted SD of 24-h SBP did notreach the statistical significance (respectively, r = 0.095and r = 0.085).The correlation of uAER with ARV of 24-hSBP, but not that with ARV of 24-h DBP, remained significanteven after adjustment for average 24-h SBP.This association remained significant (b = 0.14;p = 0.01), also taking into account the effect of age,gender, diabetes, serum uric acid, triglycerides, eGFR inmultiple regression analyses. All the other indices of shorttermBP variability tested were not independently associatedwith microalbuminuria.Conclusions: Our results seem to suggest that in essentialhypertension, short-term BP variability, only whenestimated by ARV of 24-h SBP, is independently associatedwith microalbuminuria.
Original languageEnglish
Pages (from-to)335-335
Number of pages1
JournalHIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
Volume22
Publication statusPublished - 2015

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