Sentinel hospital-based surveillance for norovirus infection in children with gastroenteritis between 2015 and 2016 in Italy

Simona De Grazia, Giovanni Giammanco, Maria Cristina Medici, Cristiana Catella, Fabio Tummolo, Anna Morea, Gianvito Lanave, Daniela Loconsole, Antonio Parisi, Flora De Conto, Maria Chironna, Vito Martella, Mariarosaria Marinaro, Adriana Calderaro, Floriana Bonura, Noemi Urone

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Noroviruses are one of the leading causes of gastro-enteric diseases worldwide in all age groups. Novel epidemic noroviruses with GII.P16 polymerase and GII.2 or GII.4 capsid type have emerged worldwide in late 2015 and in 2016. We performed a molecular epidemiological study of the noroviruses circulating in Italy to investigate the emergence of new norovirus strains. Sentinel hospital-based surveillance, in three different Italian regions, revealed increased prevalence of norovirus infection in children (<15 years) in 2016 (14.4% versus 9.8% in 2015) and the emergence of GII.P16 strains in late 2016, which accounted for 23.0% of norovirus infections. The majority of the strains with a GII.P16 polymerase showed a GII.2 capsid genotype (79.5%). Also, a marked circulation of strains with a GII.17 capsid (14.0%) was observed, chiefly in early 2016. The emergence and global spread of non-GII.4 noroviruses pose challenges for the development of vaccine strategies.
Original languageEnglish
Pages (from-to)e0208184-
Number of pages8
JournalPLoS One
Volume13
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • General

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