Self-Ordering Secondary Structure of d- and l-Arginine-Derived Polyamidoamino Acids

Nicolò Mauro, Alessio Terenzi, Alessio Terenzi, Jenny Alongi, Federica Lazzari, Giuseppina Raffaini, Elisabetta Ranucci, Fabio Ganazzoli, Paolo Ferruti, Amedea Manfredi

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11 Citations (Scopus)

Abstract

This paper reports on synthesis, acid–base properties and pH-dependent structuring in water of d-, l- and d,l-ARGO7, bioinspired polymers obtained by polyaddition of the corresponding arginine stereoisomers with N,N′-methylenebis(acrylamide). The circular dichroism spectra of d- and l-ARGO7 showed a peak at 228 nm and quickly and reversibly responded to pH changes, but were nearly unaffected by temperature, ionic strength, and denaturating agents. Theoretical modeling studies of L-ARGO7 showed that it assumed a folded structure. Intramolecular interactions led to transoid arrangements of the main chain reminiscent of the protein hairpin motif. Torsion angles showed a quite similar distribution at pH 6 and 14 consistent with the similarity of the CD spectra from pH 6 upward.
Original languageEnglish
Pages (from-to)987-991
Number of pages5
JournalACS Macro Letters
Volume6
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Materials Chemistry
  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry

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