Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

Alessio Terenzi, Alessio Terenzi, Daniela Lötsch, Bernhard K. Keppler, Dinhof, Walter Berger, Sushilla Van Schoonhoven, Domarco, Schreiber, Carlos Peinador, Marcos D. García

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.
Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalDalton Transactions
Volume46
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Inorganic Chemistry

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