Selenium a cure for autoimmune thyroiditis?

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Abstract

Autoimmune thyroiditis (AT) is a disease whose incidence has increased dramatically over the past few decades. In iodinesufficient areas, this pathological condition affects up to 5% of the general population. The higher incidence of AT observedin areas of the world with low-selenium (Se) soils apperas to be the consequence of a reduced activity of the intracellular Sedependentglutathione peroxidase activity. Se is involved, through selenoproteins, in the regulation of intracellularantioxidant, redox and anti-inflammatory processes. As a component of selenoproteins, Se exerts various structural andenzymatic functions. A low Se/high fat diet can cause selenoprotein changes and promote the expression of proinflammatoryfactors. In particular, it has been well recognized as an antioxidant and trace element catalyst essential in theproduction of thyroid hormone. Selenium is important for the functioning of the immune system. The recommended dailydose for adults of 55 μg
Original languageEnglish
Number of pages3
JournalENDOCRINE, METABOLIC & IMMUNE DISORDERS DRUG TARGETS
Publication statusPublished - 2020

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