The study of the genetic profile ofcentenarians aims to identify the genes and allelic variants which may influence a greater life expectancyand that can be considered as predisposing factors associated to the aging diseases, such as Alzheimer. Centenarians, that represent a cohort ofselected survivors, show an hypercoagulability state characterised by striking signs of high coagulationenzyme activity, as directly assessed by the tested higher plasma level of some important factors involved in the haemostasis balance. Anyway, theseindividuals seem to have a reduced susceptibility to dementia, as well as to cardiovascular events. In thisstudy we analyze the frequencies of Leiden Factor V polymorphism (G1691A), and G20210A of prothrombin (FII) in three cohorts of subjects: patientswith Alzheimer’s disease (unsuccessful aging), nonagenarians (successful aging) and young healthy controls, to assess whether allelic variants associated to the modification of haemostatic system function,may play a role in the protection or susceptibility to Alzheimer disease, as well as to reach a successful aging. No significant differences were observed in the frequencies of the three groups studied. These results indicate that the presence or absence of the genevariants examined did not influence the achievement of advanced age and are not risk factors for Alzheimer’s disease. The state of hypercoagulability and thepossession of these risk alleles appear to be compatible with the achievement of longevity and are not implied as risk factors in Alzheimer diseasedevelopment.
|Number of pages||6|
|Publication status||Published - 2011|
All Science Journal Classification (ASJC) codes
- Geriatrics and Gerontology