Role of Hsp70 in Multiple Sclerosis: An Overview

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

For many years heat shock protein 70 (Hsp70) was considered exclusively an intracellular chaperone contributing to protein proteostasis and in apoptotic pathway block. Lately it has been demonstrated that Hsp70 is actively released in the extracellular environment, thereby promoting the activation of the immune system by stimulating innate and adaptive responses through the activation of APCs. Its expression in the nervous system is induced in a variety of pathological conditions. Emerging evidences displayed that Hsp70 is a critical regulator in normal neural cells. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) directed against myelin antigens. In this review, we focus our attention on the possible protective or detrimental Hsp70 role in multiple sclerosis. A better comprehension will be useful to take advantage of its potential as a therapeutic target.
Original languageEnglish
Title of host publicationHeat Shock Proteins in Neuroscience
Pages149-167
Number of pages19
Publication statusPublished - 2019

Publication series

NameHEAT SHOCK PROTEINS

Fingerprint

HSP70 Heat-Shock Proteins
Multiple Sclerosis
Autoimmune Diseases of the Nervous System
Myelin Sheath
Nervous System
Immune System
Central Nervous System
Antigens
Proteins
Therapeutics

Cite this

Barreca, M. M., & Geraci, F. (2019). Role of Hsp70 in Multiple Sclerosis: An Overview. In Heat Shock Proteins in Neuroscience (pp. 149-167). (HEAT SHOCK PROTEINS).

Role of Hsp70 in Multiple Sclerosis: An Overview. / Barreca, Maria Magdalena; Geraci, Fabiana.

Heat Shock Proteins in Neuroscience. 2019. p. 149-167 (HEAT SHOCK PROTEINS).

Research output: Chapter in Book/Report/Conference proceedingChapter

Barreca, MM & Geraci, F 2019, Role of Hsp70 in Multiple Sclerosis: An Overview. in Heat Shock Proteins in Neuroscience. HEAT SHOCK PROTEINS, pp. 149-167.
Barreca MM, Geraci F. Role of Hsp70 in Multiple Sclerosis: An Overview. In Heat Shock Proteins in Neuroscience. 2019. p. 149-167. (HEAT SHOCK PROTEINS).
Barreca, Maria Magdalena ; Geraci, Fabiana. / Role of Hsp70 in Multiple Sclerosis: An Overview. Heat Shock Proteins in Neuroscience. 2019. pp. 149-167 (HEAT SHOCK PROTEINS).
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