RIP-Chip analysis supports different roles for AGO2 and GW182 proteins in recruiting and processing microRNA targets

Flavia Contino, Serena Bivona, Michele Tumminello, Salvatore Feo, Giorgio Bertolazzi, Giovanni Perconti, Claudia Coronnello, Patrizia Rubino, Agata Giallongo

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules mediating the translational repression and degradation of target mRNAs in the cell. Mature miRNAs are used as a template by the RNA-induced silencing complex (RISC) to recognize the complementary mRNAs to be regulated. To discern further RISC functions, we analyzed the activities of two RISC proteins, AGO2 and GW182, in the MCF-7 human breast cancer cell line
Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalBMC Bioinformatics
Volume20
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Applied Mathematics

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