Renal plasma flow, filtration fraction and microalbuminuria in hypertensive patients: Effects of chronic smoking

Silvio Buscemi, Giuseppe Andronico

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Albumin excretion rate is usually increased in people who smoke, but the physiological basis of this phenomenon is not fully understood.METHODS:The effect of chronic smoking on renal haemodynamics was studied in a cohort of 66 men. Twenty-seven were smokers and 36 were hypertensive. In all subjects, the albumin excretion rate was evaluated; in hypertensive patients, a renoscintigraphic evaluation of renal plasma flow and glomerular filtration were carried out and the filtration fraction was calculated.RESULTS:The hypertensive smoking population presented an increased urinary albumin excretion rate in comparison with hypertensive non-smoking patients. No significant differences were found for the mean values of renal plasma flow, the glomerular filtration rate and the filtration fraction between hypertensive smokers and hypertensive non-smoking patients.CONCLUSIONS:In hypertensive patients, smoking does not modify typical renal haemodynamic changes of arterial hypertension; however, it significantly increases the albumin excretion rate.
Original languageEnglish
Pages (from-to)483-486
Number of pages4
JournalNephrology
Volume10
Publication statusPublished - 2005

All Science Journal Classification (ASJC) codes

  • Nephrology

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