Renal involvement in psychological eating disorders

Giuseppe Mule', Gioacchino Li Cavoli, Ugo Rotolo, Giuseppe Mulè

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Psychological eating disorders--anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder--are an increasing public health problem with severe clinical manifestations: hypothermia, hypotension, electrolyte imbalance, endocrine disorders and kidney failure; they are of interest to nephrologists, but pathophysiological mechanisms in determining the renal involvement are still unclear. We describe pathophysiology, histological features and clinical manifestations of the most frequent psychological eating disorders: AN and BN. Regarding AN, we analyze the recent literature, and identify 3 principal pathways towards renal involvement: chronic dehydration-hypokalemia, nephrocalcinosis and chronic rhabdomyolysis. Regarding BN, we describe the correlation between obesity and many proinflammatory cytokines, chemokines, growth factors and adipokines, having potential metabolic and hemodynamic effects on the kidney and an important role in the pathogenesis of obesity-related renal injury, independently of hypertension and diabetes.
Original languageEnglish
Pages (from-to)c8-c14
Number of pages7
JournalNEPHRON CLINICAL PRACTICE
Volume117
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Nephrology

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