RELAZIONI TRA PARAMETRI LIPIDICI E MASSAVENTRICOLARE SINISTRA IN SOGGETTICON IPERTENSIONE ARTERIOSA ESSENZIALE

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Abstract

[automatically translated] no unique data are reported in the literature on the role of dyslipidemia in the development of left ventricular hypertrophy. The aim of our study was to evaluate potential associations of the main lipid parameters with the left ventricular mass (LVM) in patients with essential hypertension (EHs). We enrolled 724 patients with EH (mean age 45 ± 12 years; 63% male) with no cardiovascular complications and not treated with lipid-lowering drugs. In all subjects, the gift of total cholesterol were assayed (Tchol), triglycerides (TG) and HDL cholesterol (HDLc). LDL cholesterol (LDLc) was estimated using the Friedewald formula and has been calculated on nonHDLc cholesterol. In addition, they were performed a blood pressure monitoring 24 hours and an echocardiogram. LVM was indexed for body surface area (LVMI). No statistically significant correlation was observed between Tchol, LDLc and nonHDLc and LVMI. We found significant correlations of LVMI with HDLc (r = -0.14, p <0.0005) and with TG (r = 0:11; p = 0.003). The TG / HDLc ratio was significantly correlated with LVMI (r = 0,16; p <0.0005). In multivariate analysis, only between the HDLc lipid parameters it maintained a significant association with LVMI (β = -0,108, p = 0.0005). When in the multivariate model, in place of TG and HDLC, was inserted, the TG / HDLc ratio, the latter showed a significant relationship with the widely LVMI (β = 0.14, p <0.0001). The analysis of the interaction term "sex x TG / HDLc" did not show any significant effect of gender on the TG / HDLc relationship with LVMI. Our results suggest that among the only lipid parameters the HDLc and TG / HDLc ratio are related to the LVMI. Insulin resistance, which the TG / HDLc ratio is an expression, may mediate this relationship.
Original languageItalian
Pages162-163
Number of pages2
Publication statusPublished - 2014

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