Relazione tra indice di resistenza renale e severitàdell’aterosclerosi carotidea in soggetti conipertensione arteriosa.

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[automatically translated] RATIONAL. The intraparenchymal renal resistance index (RI), as assessed by echo-color Doppler, was classically considered mere expression of renal vascular resistance district. More recent studies, however, have shown that this index is also influenced by factors on the back, vascular compliance in the first place, to test a possible role as a marker of systemic vascular changes. Several studies have shown, moreover, as the thickness of the intima (IMTC) and plaque in the carotid level, assessed by ultrasound, they are documented markers of subclinical organ damage and progressive expressions of atherosclerotic disease. The aim of our study is to evaluate, in hypertensive subjects, the relationship between IR intrarenal and severity of atherosclerotic carotid subclinical disease. CASES AND METHODS. They were consecutively recruited 263 hypertensive subjects, aged between 30 and 70 years, with or without reduced renal function. Are all patients with renovascular hypertension and endocrine, as well as patients with carotid stenosis> 50% were excluded from the study (European Carotid Surgery Trial - ECST). The patients were divided into 3 different groups: patients with IMTc≤0.9 mme without plaques; Patients with IMTC> 0.9mme without patches; patients with plaques. All were submitted to echo-color-Doppler of the carotid and renal district. RESULTS. The IR values in the I, II and III group were respectively 0.61 ± 0:07, 0.65 ± 0.06 and 0.68 ± 0.06 (p <0.001). A strong positive correlation was observed between IR and IMTC in the whole population (r = 0:43; p <0.001) and in the subgroups with (r = 0:42; p <0.001) and without (r = 0:39; p <0.001) renal impairment. These associations remained statistically significant even after adjusting for various confounding factors in multivariate analysis. CONCLUSIONS. Our results seem to confirm a strong association between IR and severity of atherosclerotic carotid disease in hypertensive patients with and without impaired renal function, a rebuttal of a probable role of IR as a systemic vascular morphological and functional alterations marker.
Original languageItalian
Number of pages1
Publication statusPublished - 2014

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