Relazione tra disfunzione erettile, livelli di testosterone e funzione endoteliale in pazienti a rischio cardiovascolare intermedio secondo le stime della Carta di Framingham” – P259

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Abstract

[automatically translated] Scope of work The role of plasma testosterone levels and erectile dysfunction as early markers of endothelial dysfunction is not well defined. Therefore, we tried to analyze the relationship between plasma testosterone and erectile dysfunction, in relation to endothelial function. Materials and Methods We then enrolled 802 patients in primary prevention, with an intermediate cardiovascular risk estimation (CV) according to the paper of the Framingham risk, aged between 40 and 80 years, who underwent ultrasound examination of the flow expansion mediated brachial artery right, the evaluation of erectile dysfunction through the questionnaire International index of erectile function score-5 (IIEF-5), and the dosage of the plasma levels of total testosterone. The analysis results of linear regression, with the increase in testosterone levels, increased statistically significantly both endothelial function (t = 9:40; 95% CI from 0.9318 to 1.4234; p <0.0001) that erectile function (t = 8.96; 95% CI from 0.7642 to 1.1932; p <0.001) and with severe erectile dysfunction (OR 0.78, CI 0.62 -0.86), and moderate (OR 0.85, CI 0.72 to 0 , 97) with a worse endothelial function [(OR 0.68; CI 0,59- 0,79) and (OR 0.76; CI 0.63 to 0.83), respectively]. Instead, more subtle forms of erectile dysfunction such as the mild (OR 0.94; CI 0.82 - 01.07; P = 0.03) and mild to moderate (OR 0.8; CI 0.69 to 0.94; p Discussion We demonstrated a significant correlation between lower levels of total plasma testosterone, erectile dysfunction and a worse endothelial function in a population of asymptomatic individuals and intermediate cardiovascular risk. In particular, in the subgroup of patients with erectile dysfunction moderatasevera, we have seen that those who have lower levels of testosterone also the lower flow-mediated dilation percentages, and therefore a worse endothelial function. Conclusion Based on these results, we recommend the evaluation of erectile dysfunction through the IIEF-5, and assay of total plasma testosterone levels, to get a more accurate stratification of cardiovascular risk in asymptomatic patients, but with intermediate risk according to estimates the Framingham paper. in the subgroup of patients with erectile dysfunction moderatasevera, we have seen that those who have lower levels of testosterone also the lower flow-mediated dilation percentages, and therefore a worse endothelial function. Conclusion Based on these results, we recommend the evaluation of erectile dysfunction through the IIEF-5, and assay of total plasma testosterone levels, to get a more accurate stratification of cardiovascular risk in asymptomatic patients, but with intermediate risk according to estimates the Framingham paper. in the subgroup of patients with erectile dysfunction moderatasevera, we have seen that those who have lower levels of testosterone also the lower flow-mediated dilation percentages, and therefore a worse endothelial function. Conclusion Based on these results, we recommend the evaluation of erectile dysfunction through the IIEF-5, and assay of total plasma testosterone levels, to get a more accurate stratification of cardiovascular risk in asymptomatic patients, but with intermediate risk according to estimates the Framingham paper.
Original languageItalian
Pages266-266
Number of pages1
Publication statusPublished - 2014

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