RELATIONSHIPS BETWEEN DIURETIC-RELATED HYPERURICEMIA AND CARDIOVASCULAR EVENTS: DATA FROM THE URIC ACID RIGHT FOR HEART HEALTH STUDY

Carlo Maria Barbagallo, Pietro Cirillo, Fosca Quarti-Trevano, Guido Grassi, Massimo Cirillo, Francesca Mallamaci, Alessandro Maloberti, Rita Facchetti, Paolo Pauletto, Lanfranco D'Elia, Giulia Rivasi, Claudio Borghi, Bruno Bernardino, Giovambattista Desideri, Enrico Agabiti Rosei, Stefano Masi, Gesualdo Loreto, Luciano Lippa, Gianfranco Parati, Paolo VerdecchiaGuido Iaccarino, Raffaella Dell'Oro, Francesca Viazzi, Michele Bombelli, Valerie Tikhonoff, Giuliano Tocci, Arrigo Francesco Giuseppe Cicero, Roberto Pontremoli, Pietro Nazzaro, Marcello Rattazzi, Maria Lorenza Muiesan, Agostino Virdis, Massimo Salvetti, Edoardo Casiglia, Cristina Giannattasio, Ferruccio Galletti, Alberto Mazza, Andrea Ungar, Massimo Volpe, Paolo Palatini, Claudio Ferri

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Abstract

Objective: Although the relationship between hyperuricemia and cardiovascular events has been extensively examined, data on the role of diuretic-related hyperuricemia are still scanty. The present study was designed to collect information on the relationship between diuretic-related hyperuricemia and cardiovascular events.Methods: The URic acid Right for heArt Health (URRAH) study is a nationwide, multicentre, observational cohort study involving data on individuals recruited from all the Italy territory under the patronage of the Italian Society of Hypertension with an average follow-up period of 122.3 ± 66.9 months. Patients were classified into four groups according to the diuretic use (yes vs. no) and serum uric acid (SUA) levels (higher vs. lower than the median value of 4.8 mg/dl). All-cause death, cardiovascular deaths and first cardiovascular event were considered as outcomes.Results: Seventeen thousand, seven hundred and forty-seven individuals were included in the analysis. Mean age was 57.1 ± 15.2 years, men were 45.3% and SBP and DBP amounted to 144.1 ± 24.6 and 85.2 ± 13.2 mmHg. 17.2% of individuals take diuretics of whom 58% had SUA higher than median value. Patients with hyperuricemia without diuretic use served as reference group. In multivariate adjusted analysis (sex, age, SBP, BMI, glucose, total cholesterol, and glomerular filtration rate) individuals with hyperuricemia and diuretic use exhibit a similar risk for the three outcomes as compared with the reference group.Conclusion: Our study showed that diuretic-related hyperuricemia carry a similar risk of cardiovascular events and all-cause mortality when compared with individuals that present hyperuricemia in absence of diuretic therapy.
Original languageEnglish
Pages (from-to)333-340
Number of pages8
JournalJournal of Hypertension
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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