Relation of oxidant stress with endothelial activation in hemodialysis.

Francesco Vaccaro, Emilio Nardi, Giovanni Cerasola, Marco Guarneri, Giuseppe Mule', Santina Cottone, Alessandro Palermo, Anna Vadala', Rosalia Arsena

Research output: Contribution to conferenceOtherpeer-review

Abstract

Introduction and Aims: Enhanced oxidative stress may be implicated inthe pathogenesis of atherosclerosis in hemodialysed patients (HDs). Wehypothesized that in hypertensive HDs oxidative stress should be elevatedand associated to endothelial activation, and inflammation.Methods:We examined oxidative stress, as measured by 8-ISO-PGF2alpha,endothelial activation by measuring endothelin-1 (ET-1) and adhesionmolecules ICAM-1 and VCAM-1, and the biomarker of acute-phaseinflammation CRP.In 52 mild HDs and in 50 healthy controls (Cs) we analysed, in theinterdialytic day, plasma levels of 8-ISO-PGF2alpha, ET-1, ICAM-1 andVCAM-1, and high sensitivity CRP.Results: The comparison between Cs and HDs demonstrated in the lattergroup significantly higher levels of 8-ISO-PGF2alpha (p<0.0001), CRP(p<0.001), ET-1 (p< 0.001), and ICAM-1 and VCAM-1 (p<0.001).We divided successively the overall group according to tertiles of 8-ISOPGF2alpha,and we observed increasing levels of adhesion molecules, ET-1,and CRP along with the increasing tertiles, with significant differencesbetween tertiles in each parameter.The multiple regression analysis carried out considering 8-ISO-PGF2alphaas dependent variable in a model including adhesion molecules, ET-1, CRP,systolic and diastolic blood pressure, serum creatinine and glucose, age,sex, and BMI demonstrated a significant relationship of 8-ISO-PGF2alphawith VCAM-1 (Beta 0.56, p = 0.00001), and ET-1 (Beta 0.55, p = 0.0002).Conclusions: In conclusion, our findings show that in long term hypertensiveHDs oxidative stress is increased and related to endothelial activation, inthe presence of augmented index of acute inflammation.
Original languageEnglish
Pagesiv206-
Number of pages1
Publication statusPublished - 2006

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