Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension.

Giovanni Cerasola, Santina Cottone, Emilio Nardi, Marco Guarneri, Giuseppe Mule', Raffaella Riccobene, Santina Cottone, Alessandro Palermo, Anna Vadala', Chiara Briolotta, Rosalia Arsena

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Background: C-reactive protein (CRP) predicts cardiovascularoutcome. Oxidative stress is considered to beinvolved in endothelial alteration. We hypothesized that inessential hypertension (EH), oxidative stress, as measured by8-iso-prostaglandin-F2 alfa (8-iso-PGF2alfa), should be associatedwith increased CRP and endothelial activation, as evaluatedby soluble intercellular adhesion molecule–1 (ICAM-1) andvascular adhesion molecule–1 (VCAM-1) plasma levels.Methods: In 83 subjects with mild EH and in 50healthy control subjects we measured, in basal conditions,plasma levels of hs-CRP, 8-iso-PGF2 alfa, ICAM-1 andVCAM-1, and tumor necrosis factor–alfa (TNF-alfa).Results: Subjects with EH had higher levels of 8-iso-PGF2 alfa(P < .0001), CRP (P < .001), ICAM-1 andVCAM-1 (P <.001), and TNF- (P < .001) than didcontrol subjects. We divided successively EH according toCRP values (1, 1–3, 3 mg/L), and we observed increasingand significantly different levels of the endothelialparameters and of TNF- along with increasing CRP.Linear analysis of correlation pointed out significant correlationof CRP with 8-iso-PGF2 alfa (r = 0.730, P < .001),ICAM-1 and VCAM-1 (r =0.642 and 0.468, P < .001respectively), and TNF- alfa (r =0.609, P< .001).Multiple regression analysis using CRP as a dependentvariable confirmed the relationship of CRP with systolicblood pressure ( beta = 0.216, P = .039) and with 8-iso-PGF2alfa(beta 0.602, P = .0001).Conclusions: Our data demonstrate that in EH, inflammatorymolecules such as CRP and TNF-alfa are increasedand related to both oxidative stress and endothelialactivation.
Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalAmerican Journal of Hypertension
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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