Reference interval of monocyte distribution width (MDW) in healthy blood donors

Bruna Lo Sasso, Giulia Bivona, Marcello Ciaccio, Caterina Maria Gambino, Rosaria Vincenza Giglio, Luisa Agnello, Giulia Bivona, Marcello Ciaccio, Bruna Lo Sasso, Alessandro Iacona, Matteo Vidali, Alessandro Iacona, Giorgia Iacolino, Silvia Mancuso

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4 Citations (Scopus)


Background: The aim of the study was to accurately establish the reference interval (RI) of monocyte distributionwidth (MDW) in healthy blood donors by the direct method using different statistical approaches.Methods: MDW was measured in 486 subjects. RI of MDW was calculated by the non-parametric method, therobust method and, the Harrell-Davis bootstrap method and using different tests to identify potential outliers(Dixon-Reed and Tukey).Results: Lower and upper reference limits of the RI calculated by the non-parametric method were, 16.22(90%CI 15.78–16.47) – 23.15 (90%CI 22.80–24.10) (without outlier removal), and 16.44 (90%CI 16.21–16.67)– 22.99 (90%CI 22.33–23.22) (after outlier removal). The RIs based on the robust method were, respectively,16.29–22.98 (without) and 16.50–22.67 (with outlier removal). Finally, the RIs calculated by the Harrell-Davisbootstrap method, without or after outlier removal, were 16.19–23.24 and 16.43–22.93. Thus, the RIs obtainedby the three calculation methods were very similar. Additionally, no RI partition was done since no significantgender or age association was found.Conclusions: Our results support the use of a unique RI of MDW, independently of sex and age.
Original languageEnglish
Pages (from-to)272-277
Number of pages6
JournalClinica Chimica Acta
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical


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