Red Blood Cells Distribution Width as Biomarker ofWorsening in Atherosclerosis

Carmela Rita Balistreri, Antonio Pellegrino

Research output: Contribution to journalArticlepeer-review


Red blood cell Distribution Width (RDW) is a parameter of the circulating erythrocytes’ size thatit has reported to be associated with Cardiovascular Diseases (CVDs) [1-7]. The related mechanismof this association is not fully understood. However, RDW is an indicator of inflammation relatedto early inflammatory biomarkers, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumornecrosis factor-α (TNF-α) [8,9]. Accordingly, systemic chronic inflammation leads to dysfunctionalbone marrow with unsuccessful production of red blood cells [10]. As a result, it determines themigration of reticulocytes into the peripheral circulation, followed by an increase in circulating levelsof immature Red Blood Cells (RBCs), as well as in higher RDW levels
Original languageEnglish
Number of pages3
Publication statusPublished - 2018


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